Lamin B2 Monoclonal Antibody (E-3), Alexa Fluor™ 647
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA332100A647 | 50 µL | 528,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC |
Regulatory Status | RUO |
Immunogen | Extracts from chicken nuclei |
Host | Ms |
Clone Number | [E-3] |
Genebank | LMNB2 |
Isotype | IgG1,k |
Crossreactivity | Ck, Hu, Ms, Rt |
Clonality | Mab |
Format | Liquid; PBS; pH 7.4, with 1mg/mL BSA and 0.05% sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Immunocytochemistry (1-10 µg/mL) |
Purity | Protein A |
Conjugation | Alexa Fluor 647 |
Storage Conditions | 4° C, store in dark, DO NOT FREEZE! |
Disclaimer | Alternative CatNo: MA3-32100-A647 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |