Phosphatidylinositol 4,5-bisphosphate Monoclonal Antibody (2C11)

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Product Description

MA3-500 detects PIP2 from human tissues. MA3-500 has been successfully used in ELISA, Immunoprecipitation, Immunofluorescence, and Western blotting procedures. The MA3-500 antigen is liposomes containing synthetic di-palmitoyl ptdlns(4,5)P2. Phosphatidylinositol 4,5-bisphosphate or PIP2 is an important second messenger for a number of signaling processes. When certain extracellular signals are received, Phosphilipase C cleaves phosphatidylinositol into DAG and PIP2. PIP2 has been shown to interact with actin structural proteins including profiling, gelsolin, and cofilin, and demonstrates regulatory function of actin polymerization. It has also been shown to regulate vesicular transport by interacting with proteins like ADP-ribosylation factor and phospholipase D. PIP2 has also been shown to significantly affect intracellular calcium concentrations, which also regulate a variety of activities.