CACNA2D1 Monoclonal Antibody (20A)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA3921 | 100 µL | 638,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
MA3-921 detects 1,4-dihydropyridine (DHP) receptor alpha-2 subunit from human, rat, mouse, guinea pig and rabbit skeletal and cardiac muscle. MA3-921 has been successfully used in Western blot, immunocytochemistry, immunofluorescence, and immunohistochemistry procedures. By Western blot, this antibody detects a 220 kDa protein under non-reducing and a 143 kDa protein under reducing conditions representing DHP from rabbit skeletal muscle membrane preparations. Immunohistochemical staining of DHP in rabbit skeletal muscle with MA3-921 results in double rows of discrete punctate staining representing pairs of triads on the opposing sides of the Z-lines. The MA3-921 antigen is purified rabbit DHP receptor. This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Category | Antibody |
Supplier | ThermoFisher |
Application | FC, ICC, IHC, WB |
Regulatory Status | RUO |
Immunogen | Purified rabbit dihydropyridine receptor. |
Host | Ms |
Clone Number | [20A] |
Genebank | CACNA2D1 |
Isotype | IgG2a |
Crossreactivity | Gp, Hu, Ms, Rb, Rt |
Clonality | Mab |
Format | Liquid; ascites; , with 0.05% sodium azide |
Working Dilution | Flow Cytometry (1:100-1:200), Western Blot (1:500-1:1,000), Immunocytochemistry (1:250), Immunohi... |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Disclaimer | Alternative CatNo: MA3-921 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |