PARP1 Monoclonal Antibody (C-2-10)
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| MA3950 | 50 µL | 752,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This antibody does not detect PARP from chicken tissues. By Western blot, this antibody recognizes a 116 kDa protein which corresponds to PARP and the 85 kDa apoptosis-induced cleavage product of prICE and CPP32 from rat thymus extract. This antibody recognizes an epitope found between amino acids 216-375 in the DNA-binding domain of PARP. Poly ADP-Ribose Polymerase (PARP) uses nicotinamide adenine dinucleotide (oxidized form) NAD as a substrate to catalyse the transfer of ADP-ribose to a variety of nuclear protein acceptors. Proteolysis of PARP to its stable 85kDa fragment is an early marker of programmed cell death (apoptosis) and is mediated by the caspase CPP32 protein. Cleavage occurs between Adp216 and Gly217, a site in PARP conserved across species.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | EL, ICC, IHC, WB |
| Regulatory Status | RUO |
| Research Field | PROTEIN & CELL ANALYSIS |
| Immunogen | Purified calf thymus poly (ADP-ribose) polymerase. |
| Host | Ms |
| Clone Number | [C-2-10] |
| Genebank | PARP1 |
| Isotype | IgG1 |
| Crossreactivity | Bo, Hm, Hu, Ms, Primate, Rt |
| Clonality | Mab |
| Format | Liquid; ascites; , with 0.02% sodium azide |
| Working Dilution | Immunohistochemistry (Paraffin) (1:10-1:100), Western Blot (1:500), ELISA (Assay-dependent), Immu... |
| Conjugation | Unconjugated |
| Storage Conditions | Freezer (-5 to -30 C) |
| Disclaimer | Alternative CatNo: MA3-950 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Shipping Details | Wet Ice |
| Material Safety Data Sheet | Download PDF |
