PCAF Monoclonal Antibody (E.107.0)
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| MA511186 | 100 µL | 608,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
It is not recommended to aliquot this antibody. This antibody is not cross-reactive with the related GCN5L2 protein. PCAF (histone acetyltransferase KAT2B) functions as a histone acetyltransferase (HAT) to promote transcriptional activation. It has significant histone acetyltransferase activity with core histones (H3 and H4) and nucleosome core particles. PCAF also acetylates non-histone proteins such as ACLY, PLK4, and TBX5. It inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. PCAF also acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. It is involved in heart and limb development by mediating acetylation of TBX5 and acetylation regulating nucleocytoplasmic shutting of TBX5.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | ChIP, IP, WB |
| Regulatory Status | RUO |
| Immunogen | Synthetic peptide corresponding to the amino terminus of human PCAF protein |
| Host | Rb |
| Clone Number | [E.107.0] |
| Genebank | KAT2B |
| Isotype | IgG |
| Crossreactivity | Hu, Ms, Primate, Rt |
| Clonality | Mab |
| Format | Liquid; 0.01M HEPES; pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol and <0.02% sodium azide |
| Concentration | 358 µg/mL |
| Working Dilution | Western Blot (1:1,000), Immunoprecipitation (1:100), ChIP Assay (1:25) |
| Purity | Affinity chromatography |
| Conjugation | Unconjugated |
| Storage Conditions | -20°C |
| Disclaimer | Alternative CatNo: MA5-11186 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
