CTCF Monoclonal Antibody (G.758.4)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA511187 | 100 µL | 682,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
It is not recommended to aliquot this antibody. This antibody is not cross-reactive with BORIS. Transcriptional factor CTCF is a ubiquitously expressed 11-zinc finger domain containing, DNA-binding nuclear phosphoprotein that is involved in multiple aspects of normal gene regulation including transcriptional repression and activation, gene silencing, chromatin insulation and regulation of imprinted sites. CTCF uses different combinations of ZF domains and interacts with the CCCTC motif on the DNA. It can bind to HAT- and HDAC-containing complexes thereby influencing transcriptional activation or repression respectively. It is a multifunctional protein involved in the transactivation of APPB gene, silencing of c-myc gene, and insulation of human beta-globin and DMI myotonic dystrophy locus and imprinting control of IGF2 and H19 regions. CTCF has also been shown to regulate the transcription of Pax6 and IRAK2 promoter thereby opening a therapeutic avenue. Mutations in this gene have been associated with invasive breast cancers, prostate cancers and Wilms' tumors.
Category | Antibody |
Supplier | ThermoFisher |
Application | ChIP, ICC, IHC, IP, WB |
Regulatory Status | RUO |
Immunogen | Synthetic peptide corresponding to the carboxy terminus of the human CTCF protein |
Host | Rb |
Clone Number | [G.758.4] |
Genebank | CTCF |
Isotype | IgG |
Crossreactivity | Hu, Ms, Primate, Rt |
Clonality | Mab |
Format | Liquid; 0.01M HEPES; pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol and <0.02% sodium azide |
Concentration | 91 µg/mL |
Working Dilution | Western Blot (1:1,000), Immunoprecipitation (1:50), Immunohistochemistry (Paraffin) (1:640 - 1:25... |
Purity | Affinity chromatography |
Conjugation | Unconjugated |
Storage Conditions | -20°C |
Disclaimer | Alternative CatNo: MA5-11187 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |