H3K4me3 Monoclonal Antibody (G.532.8)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA511199 | 100 µL | 602,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
It is not recommended to aliquot this antibody. This antibody is not cross-reactive with methylated histone H3 Lys9, Lys27, Lys36 or methylated histone H4 Lys20. Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modification that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC, IHC, WB |
Regulatory Status | RUO |
Immunogen | Synthetic peptide corresponding to the amino terminus of histone H3 in which Lys4 is tri-methylated |
Host | Rb |
Clone Number | [G.532.8] |
Genebank | H3C1 |
Isotype | IgG |
Crossreactivity | Drosophila, Hu, Ms, Primate, Rt, Yeast |
Clonality | Mab |
Format | Liquid; 0.01M HEPES; pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol and <0.02% sodium azide |
Concentration | 241 µg/mL |
Working Dilution | Immunocytochemistry (1:400), Peptide array (1:2,000), Western Blot (1:1,000), Immunohistochemistr... |
Purity | Affinity chromatography |
Conjugation | Unconjugated |
Storage Conditions | -20°C |
Disclaimer | Alternative CatNo: MA5-11199 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |