Cytokeratin 14 Monoclonal Antibody (LL002)

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Product Description

MA5-11599 targets Cytokeratin 14 in IHC (P) and WB applications and shows reactivity with Human and Rat samples. The MA5-11599 immunogen is a synthetic peptide of 15 amino acid residues from the C-terminus of human keratin 14. Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie. skin) and non-keratinizing cells (ie. mesothelial cells). At least 20 different CKs can be identified. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). Belonging to the type I subfamily of low molecular weight keratins and existing in combination with keratin 5, keratin 14 distinguishes stratified epithelial cells from simple epithelial cells and is useful in identification of squamous cell carcinomas. It is considered a prognostic marker in breast carcinomas. At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells.