Involucrin Monoclonal Antibody (SY5)
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| MA511803 | 500 µL | 666,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
MA5-11803 targets Involucrin in ELISA, IF, IHC (P), IP, and WB applications and shows reactivity with Canine, Human, Non-human primate, Porcine, and Rat samples. The MA5-11803 immunogen is human keratinocytes' involucrin. Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures it is expressed by all cells that have left the basal layer. Involucrin expression is abnormal in squamous cell carcinomas and premalignant lesions and is reduced in severe dysplasias of the larynx and cervix. Its gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | EL, IHC, IP, WB |
| Regulatory Status | RUO |
| Research Field | PROTEIN & CELL ANALYSIS |
| Immunogen | Human keratinocytes' involucrin |
| Host | Ms |
| Clone Number | [SY5] |
| Genebank | IVL |
| Isotype | IgG1,k |
| Crossreactivity | Dg, Hu, Primate, Pg, Rt |
| Clonality | Mab |
| Format | Liquid; PBS; pH 7.4, with 0.05% BSA and 0.05% sodium azide |
| Concentration | 0.2 mg/mL |
| Working Dilution | ELISA (Assay-dependent), Immunohistochemistry (Paraffin) (1:100-200), Immunoprecipitation (2 µg/m... |
| Purity | Protein A/G |
| Conjugation | Unconjugated |
| Storage Conditions | Cold Room (2 to 8 C) |
| Disclaimer | Alternative CatNo: MA5-11803 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Shipping Details | Ambient |
| Material Safety Data Sheet | Download PDF |
