PTEN Monoclonal Antibody (17.A)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA512278 | 500 µL | 660,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
MA5-12278 targets PTEN in WB, IHC and ICC/IF applications and shows reactivity with Human and Mouse samples. The MA5-12278 immunogen is recombinant human PTEN protein. PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The PTEN gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. PTEN negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. PTEN plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Also, PTEN may be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form of PTEN induc
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC, IHC, WB |
Regulatory Status | RUO |
Immunogen | Recombinant human PTEN protein |
Host | Ms |
Clone Number | [17.A] |
Genebank | PTEN |
Isotype | IgM,k |
Crossreactivity | Hu, Ms |
Clonality | Mab |
Format | Liquid; Tissue culture supernatant, with 0.09% sodium azide |
Working Dilution | Immunohistochemistry (Paraffin) (1:50-1:200), Western Blot (1:10-1:100), Immunocytochemistry (1:1... |
Conjugation | Unconjugated |
Storage Conditions | 4° C |
Disclaimer | Alternative CatNo: MA5-12278 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |