Ku70/Ku80 Monoclonal Antibody (162)

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Product Description

MA5-12938 targets Ku (p70/p80) in FACS, GS, ICC/IF, and IHC (P) applications and shows reactivity with Human, Non-human primate, Mouse and Xenopus laevis samples. This antibody does not cross-react with mouse in immunofluorescent applications, but does react with mouse in FACS applications. The MA5-12938 immunogen is human B cell nuclei from plasmacytoid 2p68 cells. The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008].