COL7A1 Monoclonal Antibody (LH7.2)

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Product Description

MA5-13432 targets Collagen VII in IF, IHC (F), and IM applications and shows reactivity with Bovine, Guinea Pig, Goat, Human, Non-human primate, Ovine, and Porcine samples. The MA5-13432 immunogen is insoluble fractions of human neonatal foreskin epidermal cells. This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen. [provided by RefSeq, Jul 2008].