INSR Monoclonal Antibody (CT-3)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA513783 | 500 µL | 504,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
MA5-13783 targets Insulin Receptor beta in ELISA, ICC/IF, IHC (P), Affinity Purification, and WB applications and shows reactivity with Human, mouse, Non-human primate, and Rat samples. The MA5-13783 immunogen is recombinant-fragment including the C-terminal 100 amino acids of human insulin receptor. INSR (insulin receptor, IR) is a heterodimeric protein complex that has an intracellular beta subunit and an extracellular alpha subunit, which is disulfide- linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intracellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are the cause of various insulin resistance syndromes and IGF-1R defects may also cause some forms of growth retardation.
Category | Antibody |
Supplier | ThermoFisher |
Application | AP, EL, ICC, IHC, WB |
Regulatory Status | RUO |
Immunogen | Recombinant-fragment including the C-terminal 100 amino acids of human insulin receptor |
Host | Ms |
Clone Number | [CT-3] |
Genebank | INSR |
Isotype | IgG1 |
Crossreactivity | Hu, Ms |
Clonality | Mab |
Format | Liquid; PBS; pH 7.4, with 0.2% BSA and 0.09% sodium azide |
Concentration | 50 µg/mL |
Working Dilution | Affinity Purification (Assay-dependent), ELISA (Assay-dependent), Immunocytochemistry (1:10-1:100... |
Purity | Protein G |
Conjugation | Unconjugated |
Storage Conditions | 4° C |
Disclaimer | Alternative CatNo: MA5-13783 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |