c-Abl Monoclonal Antibody (8E9)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA514398 | 500 µL | 668,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
MA5-14398 targets c-Abl in immunofluorescence, immunoprecipitation, immunohistochemistry (paraffin), and Western blot applications and shows reactivity with Human. The MA5-14398 immunogen is recombinant Abl protein. c-Abl (Abelson murine leukemia viral oncogene homolog 1, ABL1) is a 140 kDa proto-oncogene member of the Src family of non-receptor tyrosine kinases. c-Abl has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns c-Abl into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR and c-Abl genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for c-Abl. In chronic myelogenous leukemia and a subset of acute lymphoblastic leukemias, the c-Abl proto oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome) As the result of the fusion of c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this transloca
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC, IHC, IP, WB |
Regulatory Status | RUO |
Immunogen | Recombinant Abl protein |
Host | Ms |
Clone Number | [8E9] |
Genebank | ABL1 |
Isotype | IgG1,l |
Crossreactivity | Hu |
Clonality | Mab |
Format | Liquid; PBS; pH 7.4, with 0.2% BSA and 0.09% sodium azide |
Concentration | 0.2 mg/mL |
Working Dilution | Western Blot (1:50), Immunocytochemistry (1:10-1:100), Immunoprecipitation (2 µg/mg protein lysat... |
Purity | Protein G |
Conjugation | Unconjugated |
Storage Conditions | 4° C |
Disclaimer | Alternative CatNo: MA5-14398 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |