alpha-1 Antitrypsin Monoclonal Antibody (TMF1#4B5)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA514661 | 100 µg | 638,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
MA5-14661 targets Alpha1-Antitrypsin in ELISA, IP, and RIA applications and shows reactivity with Human samples. The MA5-14661 immunogen is purified human a1-Antitrypsin. MA5-14661 detects Alpha1-Antitrypsin which has a predicted molecular weight of approximately 46 kDa. Product MA514661 is a smaller package size of MIA1101 (formerly sold as a Seradyn product). Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn. Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
Category | Antibody |
Supplier | ThermoFisher |
Application | EL, FC, IP, RIA, WB |
Regulatory Status | RUO |
Immunogen | Purified human a1-Antitrypsin |
Host | Ms |
Clone Number | [TMF1#4B5] |
Genebank | SERPINA1 |
Isotype | IgG2a |
Crossreactivity | Hu, Ms |
Clonality | Mab |
Format | Liquid; PBS; pH 7.4, with 1mg/mL BSA and 0.05% sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Flow Cytometry (3-5 µg/1x10^6 cells), Radioimmune assays (Assay-dependent), ELISA (Assay-dependen... |
Purity | Protein A |
Conjugation | Unconjugated |
Storage Conditions | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C |
Disclaimer | Alternative CatNo: MA5-14661 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |