SETD8 Monoclonal Antibody (B.540.4)
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| MA514804 | 100 µL | 682,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
It is not recommended to aliquot this antibody. SETD8 is a histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. The protein mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. It is required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. It is also involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | ICC, WB |
| Regulatory Status | RUO |
| Research Field | PROTEIN & CELL ANALYSIS |
| Immunogen | Synthetic peptide corresponding to human SET8 protein |
| Host | Rb |
| Clone Number | [B.540.4] |
| Genebank | KMT5A |
| Isotype | IgG |
| Crossreactivity | Bo, Ho, Hu, Ms, Primate, Pg, Rt |
| Clonality | Mab |
| Format | Liquid; 0.01M HEPES; pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol and <0.02% sodium azide |
| Working Dilution | Immunocytochemistry (1:100), Western Blot (1:1,000) |
| Purity | Antigen affinity chromatography |
| Conjugation | Unconjugated |
| Storage Conditions | Freezer (-5 to -30 C) |
| Disclaimer | Alternative CatNo: MA5-14804 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Shipping Details | Wet Ice |
| Material Safety Data Sheet | Download PDF |
