Phospho-ZAP70/Syk (Tyr319, Tyr352) Monoclonal Antibody (R.658.6)
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| MA515095 | 100 µL | 606,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
It is not recommended to aliquot this antibody. ZAP70, a 70 kDa member of the Syk tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315 and 319 in the interdomain B, located between the SH2 and kinase domains. Phosphorylation of both tyrosines 315 (a Vav binding site) and 319 (a Lck binding site) enhances ZAP70 function in mediating lymphocyte signaling, while tyrosine 292 terminates the transient activation of ZAP70 and attentuates lymphocyte signaling.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | WB |
| Regulatory Status | RUO |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pTyr319 of human Zap-70 |
| Host | Rb |
| Clone Number | [R.658.6] |
| Genebank | ZAP70 |
| Isotype | IgG |
| Crossreactivity | Bo, Dg, Ck, Ho, Hm, Hu, Ms, Primate, Pg, Rt |
| Clonality | Mab |
| Format | Liquid; 0.01M HEPES; pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol and <0.02% sodium azide |
| Working Dilution | Western Blot (1:1,000) |
| Purity | Affinity chromatography |
| Conjugation | Unconjugated |
| Storage Conditions | -20°C |
| Disclaimer | Alternative CatNo: MA5-15095 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
