STAT6 Monoclonal Antibody (7D3)

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Product Description

MA5-15659 targets STAT6 in IF and WB applications and shows reactivity with Human, mouse, Non-human primate, and Rat samples. The MA5-15659 immunogen is purified recombinant fragment of human STAT6 expressed in E. Coli. MA5-15659 detects STAT6 which has a predicted molecular weight of approximately 94kDa. STAT6 protein is a transcription factor activated by cytokines, particularly interleukin-4 and IL13. (Stat6-/-) were found to be deficient in IL-4-mediated functions including Th2 helper T-cell differentiation, expression of cell surface markers, T-cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL-4 mediated proliferation. STAT6 mRNA has been detected in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung and placenta. STAT6 is critically involved in Th2 immune response. STAT6 is crucial for IL-4-mediated biological responses, and naturally in two isoforms: STAT6a and STAT6c.