HIF-1 beta Monoclonal Antibody (H1beta234), DyLight™ 488
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA516013 | 100 µL | 606,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products. Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis. This occurs as a posttranslational modification by prolyl hydroxylation. HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits. Both subunits are constantly translated. However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes. Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity. Therefore, the concentration of HIF-1 alpha increases in the cell. In contrast, HIF-1 beta remains stable under either condition. HIF-1 beta is a serie
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC, IHC, WB |
Regulatory Status | RUO |
Immunogen | Fusion protein containing amino acids 496-789 of human HIF-1 beta. |
Host | Ms |
Clone Number | [H1beta234] |
Genebank | ARNT |
Isotype | IgG1,k |
Crossreactivity | Bo, Ferret, Hu, Ms, Primate, Sh, Rt |
Clonality | Mab |
Format | Liquid; 50mM sodium borate; , with no preservative |
Concentration | 1.4 mg/mL |
Working Dilution | Immunohistochemistry (Paraffin) (1:100), Western Blot (1:500), Immunocytochemistry (Assay-Dependent) |
Purity | Protein G |
Conjugation | DY 488 |
Storage Conditions | 4° C, store in dark |
Disclaimer | Alternative CatNo: MA5-16013 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |