Desmoglein 3 Monoclonal Antibody (5G11)
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| MA516025 | 100 µL | 658,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is predominately expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus. Desmoglein 3 has been characterized as the auto-antigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies causes the loss of cell-cell adhesion, which clinically manifests as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | DB, FC, ICC, IHC, IP, WB |
| Regulatory Status | RUO |
| Immunogen | Human Desmoglein 3 recombinant protein. |
| Host | Ms |
| Clone Number | [5G11] |
| Genebank | DSG3 |
| Isotype | IgG1 |
| Crossreactivity | Hu |
| Clonality | Mab |
| Format | Liquid; PBS; , with 0.02% sodium azide |
| Concentration | 1 mg/mL |
| Working Dilution | Western Blot (1:500-1:1,000), Flow Cytometry (1 µg per million cells), Immunocytochemistry (1:100... |
| Purity | Protein G |
| Conjugation | Unconjugated |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Disclaimer | Alternative CatNo: MA5-16025 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
