BUBR1 Monoclonal Antibody (8G1), DyLight™ 488
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| MA516037 | 100 µL | 600,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
BUBR1 is a member of the Ser/Thr protein kinase family. It is a component of the mitotic checkpoint that delays anaphase until all chromosome are properly attached to the mitotic spindle. Compromised spindle checkpoints are thought to play an important role in genetic instability that predisposes cells to malignant transformations. Human cells contain two related checkpoint protein kinases, evolved from the BUB1 gene; hBUBR1 and hBUB1. They are important components of the spindle checkpoint Both kinases monitor mitotic kinetochore-microtubule interactions. hBUBR1 is essential for normal mitotic progression as it prevents cells from entering into anaphase too early. BUBR1 has been detected in human cancers. It has been identified as a novel binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which has been suggested to accelerate the progression of breast cancer by compromising the mitotic checkpoint control through inactivation of BUBR1.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | FC, ICC, WB |
| Regulatory Status | RUO |
| Immunogen | A portion of hBUBR1 tagged at the N-terminus with pMAL (residues 1-350 of human BUBR1). |
| Host | Ms |
| Clone Number | [8G1] |
| Genebank | BUB1B |
| Isotype | IgG1,k |
| Crossreactivity | Hu, Ms |
| Clonality | Mab |
| Format | Liquid; 50mM sodium borate; , with no preservative |
| Concentration | 0.6 mg/mL |
| Working Dilution | Flow Cytometry (Assay-Dependent), Western Blot (1:2,000-1:5,000), Immunocytochemistry (1:100) |
| Purity | Protein G |
| Conjugation | DY 488 |
| Storage Conditions | 4° C, store in dark |
| Disclaimer | Alternative CatNo: MA5-16037 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
