BRCA1 Monoclonal Antibody (KEN), DyLight™ 650
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA516051 | 100 µL | 606,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Suggested positive control: U2OS and MCF-7 whole cell lysates. BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor in combination with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex). BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex. The BRCA1 protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC, WB |
Regulatory Status | RUO |
Immunogen | Human BRCA1 (residues 1314-1864). |
Host | Ms |
Clone Number | [KEN] |
Genebank | BRCA1 |
Isotype | IgG3,k |
Crossreactivity | Hu |
Clonality | Mab |
Format | Liquid; 50mM sodium borate; , with 0.05% sodium azide |
Concentration | 1.0 mg/mL |
Working Dilution | Western Blot (2-4 µg/mL), Immunocytochemistry (1:100) |
Purity | Protein A |
Conjugation | DY 650 |
Storage Conditions | 4° C, store in dark |
Disclaimer | Alternative CatNo: MA5-16051 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |