CIP2A Monoclonal Antibody (2G10), DyLight™ 550
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| MA516084 | 100 µL | 606,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, CIP2A promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A. Importantly, CIP2A is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | FC, ICC, IHC, WB |
| Regulatory Status | RUO |
| Immunogen | A C-terminal portion of the human p90 protein. |
| Host | Ms |
| Clone Number | [2G10] |
| Genebank | CIP2A |
| Isotype | IgG2b,k |
| Crossreactivity | Hu, Ms, Primate, Rt |
| Clonality | Mab |
| Format | Liquid; 50mM sodium borate; , with no preservative |
| Concentration | 1.8 mg/mL |
| Working Dilution | Western Blot (0.5-2 µg/mL), Immunocytochemistry (Assay-Dependent), Flow Cytometry (Assay-Dependen... |
| Purity | Protein G |
| Conjugation | DY 550 |
| Storage Conditions | 4° C, store in dark |
| Disclaimer | Alternative CatNo: MA5-16084 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
