TLR3 Monoclonal Antibody (40C1285.6)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA516184 | 100 µg | 658,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
TLR3 (Toll-like receptor 3, CD283) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from drosophila to humans and share structural and functional similarities. TLRs recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR3 is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. TLR3 recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. Further, TLR3 may play a role in host defense against viruses, and the use of alternative polyadenylation sites to generate different length transcripts has been noted for the TLR3 gene. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs charact
Category | Antibody |
Supplier | ThermoFisher |
Application | FC, ICC, IHC, IP, N, WB |
Regulatory Status | RUO |
Immunogen | A synthetic peptide corresponding to amino acids 55-85 of human TLR3 was used as immunogen. |
Host | Ms |
Clone Number | [40C1285.6] |
Genebank | TLR3 |
Isotype | IgG1,k |
Crossreactivity | Dg, Hu, Ms |
Clonality | Mab |
Format | Liquid; PBS; , with 0.05% sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Flow Cytometry (2-4 µg per million cells), Immunocytochemistry (1:10-1:500), Immunohistochemistry... |
Purity | Protein G |
Conjugation | Unconjugated |
Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Disclaimer | Alternative CatNo: MA5-16184 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |