TLR2 Monoclonal Antibody (TL2.1)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA516200 | 100 µg | 544,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Suggested positive control: antigen standard for TLR2 (transient overexpression lysate), PBMCs, Ramos. TLR2 is a member of the Toll-like receptor (TLR) family which play a fundamental role in pathogen recognition and activation of innate immunity. TLR proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kappa-B. TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer, can recognize a variety of bacterial and mycoplasma lipoproteins respectively. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The various TLRs exhibit different patterns of expression. TLR2 is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. TLR2 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Ten human homologs of TLRs (TLR1-10) have been described. TLR2 is expressed in human cells such as tonsils, microglia, lymph nodes, and appendices, activated B-cells in
Category | Antibody |
Supplier | ThermoFisher |
Application | DB, EL, FC, ICC, IP, N, WB |
Regulatory Status | RUO |
Immunogen | CHO cells transfected with human TLR2 cDNA |
Host | Ms |
Clone Number | [TL2.1] |
Genebank | TLR2 |
Isotype | IgG2a |
Crossreactivity | Dg, Hu, Ms, Rb, Rt |
Clonality | Mab |
Format | Liquid; PBS; , with 0.02% sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Functional Assay (Assay-Dependent), Flow Cytometry (1 µg per million cells), Immunocytochemistry ... |
Purity | Protein G |
Conjugation | Unconjugated |
Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Disclaimer | Alternative CatNo: MA5-16200 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |