beta Tubulin Loading Control Monoclonal Antibody (BT7R), DyLight™ 680
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA516308D680 | 50 µL | 347,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
MA5-16308-D680 has successfully been used in immunofluorescence and Western blot applications. DyLight 680 has an excitation/emission of 692/712 nm. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Beta-III tubulin is primarily expressed in neurons and may be involved in neurogenesis, axon guidance and maintenance. Mutations in the beta tubulin gene are the cause of congenital fibrosis of the extraocular muscles type 3. Beta-III tubulin was also detected in Sertoli cells of the testis and transiently in non-neuronal embryonic tissues. Glutamate residues at the C-terminus of beta III tubulin can be glutamylated. The precise function of such modifications is unclear. Tubulin is phosphorylated on Ser-172 by CDK1 during cell cycle progression. Ser-172 phosphorylation inhibits tubulin incorporation into microtubules.Microtubules, the major cytoskeletal elements found in all eukaryotic cells, consist of Tubulin, which is a dimer of two 55 kDa subunits: alpha and Beta. Microtubules play key roles in chromosome segregation in mitosis, intracellular transport, ciliary and flagellar bending, and structural support of the cytoskeleton. Because beta-tubulin is ubiquitously expressed in all euk
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC, WB |
Regulatory Status | RUO |
Immunogen | KLH conjugated peptide of the N-terminus of Beta-Tubulin. |
Host | Ms |
Clone Number | [BT7R] |
Genebank | TUBB |
Isotype | IgG2a |
Crossreactivity | Dg, Ck, Hu, Ms, Primate, Rb, Rt |
Clonality | Mab |
Format | Liquid; PBS; , with proprietary stabilizer and 0.02% sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Western Blot (1 µg/mL), Immunocytochemistry (1:25-1:100) |
Purity | Protein A |
Conjugation | DY 680 |
Storage Conditions | 4° C, do not freeze |
Disclaimer | Alternative CatNo: MA5-16308-D680 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |