CD21 Monoclonal Antibody (CA2.1D6), PE

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Product Description

MA5-16609 should not be used with MA5-16605 (mouse anti-canine CD3), in dual color flow cytometry, due to non-specific interactions between the two reagents. For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL. Reconstitute with 1 mL of distilled water. After reconstitution, store product undiluted at 4ºC in the dark. Mouse anti Canine CD21 antibody, clone CA2.1D6 recognizes canine CD21, also known as Complement receptor type 2. CD21 is a cell surface antigen expressed by canine B lymphocytes. CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to follicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands. CD21 functions as receptor f