CD14 Monoclonal Antibody (TÜK4)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA516956 | 500 µg | 824,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This product is a low-endotoxin, preservative-free formulation. Endotoxin level is <0.01 EU/ug. For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL. CD14 is a 55 kDa GPI-anchored glycoprotein that is constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils. CD14 also serves as a multifunctional lipopolysaccharide receptor, and is released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 can discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. Further, CD14 has been shown to bind apoptotic cells, and can affect allergic, inflammatory and infectious processes. Alternative splicing results in multiple transcript variants encoding the same CD14 isoform. Diseases associated with CD14 dysfunction include mycobacterium chelonae infection and Croup.
Category | Antibody |
Supplier | ThermoFisher |
Application | EL, FC, WB |
Regulatory Status | RUO |
Immunogen | The details of the immunogen for this antibody are not currently available. |
Host | Ms |
Clone Number | [TÜK4] |
Genebank | CD14 |
Isotype | IgG2a |
Crossreactivity | Bo, Camelid, Dg, Cynomolgus Monkey, Ca, Gt, Hu, Mink, Sh, Pg, Rb |
Clonality | Mab |
Format | Liquid; PBS; , with no preservative |
Concentration | 1 mg/mL |
Working Dilution | Western Blot (Assay-dependent), ELISA (Assay-dependent), Functional Assay (Assay-dependent), Flow... |
Purity | Protein A |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Disclaimer | Alternative CatNo: MA5-16956 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |