GAD65 Monoclonal Antibody (144)
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| MA518053 | 100 µL | 838,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This target has a predicted molecular weight of 65 kDa. GAD65 (glutamic acid decarboxylase-65) are present in autoimmune disorders such as insulin-dependent (type1) diabetes mellitus (IDDM), stiff man syndrome and polyendocrine autoimmune disease. Auto-antibodies to GAD65 are present in 60-70% of individuals with newly diagnosed IDDM and thus are important markers for disease activity. These auto-antibodies usually recognize conformation-dependent regions on GAD65 and rarely bind to the second isoform, GAD67. Auto-antibodies to GAD67 are found in only 15% of recent-onset IDDM patients and most of this binding can be blocked with GAD65, suggesting shared epitopes between the two isoforms of GAD.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | FC, IP, RIA, WB |
| Regulatory Status | RUO |
| Research Field | PROTEIN & CELL ANALYSIS |
| Immunogen | Synthetic peptide: GSGFWSFGSEDGSGDSEN conjugated to KLH, corresponding to amino acids 4-22 of Human GAD65 |
| Host | Ms |
| Clone Number | [144] |
| Genebank | GAD2 |
| Isotype | IgG1 |
| Crossreactivity | Hu, Ms, Rt |
| Clonality | Mab |
| Format | Liquid; PBS; , with 0.09% sodium azide |
| Concentration | 1 mg/mL |
| Working Dilution | Flow Cytometry (Assay-dependent), Immunoprecipitation (Assay-dependent), Radioimmune assays (Assa... |
| Purity | Protein A/G |
| Conjugation | Unconjugated |
| Storage Conditions | Freezer (-5 to -30 C) |
| Disclaimer | Alternative CatNo: MA5-18053 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Shipping Details | Ambient |
| Material Safety Data Sheet | Download PDF |
