beta-2 Microglobulin Monoclonal Antibody (B2M-01), Alexa Fluor™ 647
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA518119 | 100 µg | 544,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This antibody reacts with beta2-microglobulin associated with cell-surface MHC Class I molecules and other membrane antigens as well as with soluble beta2-microglobulin. It will not cross-react with mouse, rabbit, canine, chicken or bovine. Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells. Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. Levels of beta 2 microglobulin can be us
Category | Antibody |
Supplier | ThermoFisher |
Application | FC, ICC, WB |
Regulatory Status | RUO |
Immunogen | Purified human beta2-microglobulin |
Host | Ms |
Clone Number | [B2M-01] |
Genebank | B2M |
Isotype | IgG2a |
Crossreactivity | Hu |
Clonality | Mab |
Format | Liquid; PBS; pH 7.4, with 15mM sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Western Blot (Assay-dependent), Flow Cytometry (1-5 µg/mL), Immunocytochemistry (Assay-dependent) |
Purity | Size-exclusion chromatography |
Conjugation | Alexa Fluor 647 |
Storage Conditions | 4° C, store in dark, DO NOT FREEZE! |
Disclaimer | Alternative CatNo: MA5-18119 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |