CD11b Monoclonal Antibody (ICRF44), Alexa Fluor™ 488
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA518124 | 100 Tests | 554,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). CD11b is expressed on the surface of monocytes/macrophages, granulocytes, activated lymphocytes, a subset of NK cells, a subset of dendritic cells, and microglia in the brain. CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X -these adhesions are critical for cell-cell and cell-matrix interactions. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Further, peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages. Diseases associated with CD11b dysfunction include systemic lupus erythematosus 6 and ITGAM-related susceptibility to systemic lupus erythematosus.
Category | Antibody |
Supplier | ThermoFisher |
Application | FC, ICC |
Regulatory Status | RUO |
Immunogen | Rheumatoid synovial cells and human monocytes |
Host | Ms |
Clone Number | [ICRF44] |
Genebank | ITGAM |
Isotype | IgG1 |
Crossreactivity | Hu, Primate |
Clonality | Mab |
Format | Liquid; PBS; pH 7.4, with 0.2% BSA and 15mM sodium azide |
Working Dilution | Flow Cytometry (4 µLx100 µL whole blood or 10^6 cells), Immunocytochemistry (Assay-dependent) |
Purity | Size-exclusion chromatography |
Conjugation | Alexa Fluor 488 |
Storage Conditions | 4° C, store in dark, DO NOT FREEZE! |
Disclaimer | Alternative CatNo: MA5-18124 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |