CD16 Monoclonal Antibody (3G8), Alexa Fluor™ 488
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA518127 | 100 Tests | 554,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
CD16 (FCGR3A) is a 50-65 kDa cell surface molecule that exists in two forms - a transmembranous form expressed by NK cells and some T cells, and a phosphatidylinositol linked form expressed by granulocytes. CD16 is a low affinity receptor for IgG (FcR III), and is an important receptor mediating ADCC by NK cells. Human CD16 is expressed in two forms – FCGR3A and FCGR3B. FCGR3A is associated with the FcepsilonRI-gamma subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell FCGR3A is associated, with FcepsilonRI-beta subunit. Besides IgG, FCGR3A can be triggered also by oligomeric IgE. FCGR3B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a pro-adhesive phenotype. Diseases associated with CD16 dysfunction include immunodeficiency 20 and systemic lupus erythematosus.
Category | Antibody |
Supplier | ThermoFisher |
Application | FC |
Regulatory Status | RUO |
Immunogen | Human neutrophils |
Host | Ms |
Clone Number | [3G8] |
Genebank | FCGR3A |
Isotype | IgG1,k |
Crossreactivity | Hu, Primate |
Clonality | Mab |
Format | Liquid; PBS; pH 7.4, with 0.2% BSA and 15mM sodium azide |
Working Dilution | Flow Cytometry (4 µLx100 µL whole blood or 10^6 cells) |
Purity | Size-exclusion chromatography |
Conjugation | Alexa Fluor 488 |
Storage Conditions | 4° C, store in dark, DO NOT FREEZE! |
Disclaimer | Alternative CatNo: MA5-18127 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |