IGF2R Monoclonal Antibody (MEM-238), Alexa Fluor™ 647
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA518132 | 100 Tests | 459,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This antibody recognizes an epitope between domains 2 and 5 of CD222 (IGF2 receptor), a ubiquitously expressed 250 kDa multifunctional type I transmembrane protein. The majority of CD222 is found in the late endosomal/prelysosomal compartment, 5-10% in the plasma membrane and the truncated (220 kDa) form of CD222 is present in human and bovine serum. Lysosomal enzymes containing one or two mannose 6-phosphate (man6P) moieties are moved about in the cell by two distinct but interconnected cycles by means of approximately 300 kDa cation independent mannose 6-phospate receptors (CI-MPR). The biosynthetic cycle refers to the MPR transport of newly synthesized lysosomal enzymes from the trans Golgi network to late endosomes or early lysosomes. The endocytic cycle transports extracellular lysosomal enzymes from the plasma membrane via clathrin-coated vesicles to early endosomes. The entire pool of MPRs cycles between these cellular compartments every 3 hours. The steady state distribution of MPR's is predominantly within late endosomes, fewer in the trans Golgi network and approximately 10 % at cell surface. In addition to its man6P binding activity, the MPR contains a separate binding site for the type II insulin-like growth factor and is capable of binding both man6P
Category | Antibody |
Supplier | ThermoFisher |
Application | FC, WB |
Regulatory Status | RUO |
Immunogen | Recombinant Vaccinia virus encoding CD222 |
Host | Ms |
Clone Number | [MEM-238] |
Genebank | IGF2R |
Isotype | IgG1 |
Crossreactivity | Hu, Primate |
Clonality | Mab |
Format | Liquid; PBS; pH 7.4, with 0.2% BSA and 15mM sodium azide |
Working Dilution | Flow Cytometry (4 µLx100 µL whole blood or 10^6 cells), Western Blot (Assay-dependent) |
Purity | Size-exclusion chromatography |
Conjugation | Alexa Fluor 647 |
Storage Conditions | 4° C, store in dark, DO NOT FREEZE! |
Disclaimer | Alternative CatNo: MA5-18132 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |