IL-10 Monoclonal Antibody (25209)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA523716 | 500 µg | 658,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
In Western blots, this antibody does not cross-react with recombinant mouse IL-10. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method. Interleukin 10 (IL-10, CSIF) is an anti-inflammatory cytokine mainly produced by macrophages and Th2 cells. IL-10 is an 18.6 kDa protein of 160 amino acid residues that shares over 80% sequence homology with the Epstein-Barr Virus protein (BCRFI). The reported biological activities of IL-10, which maybe interrelated, include inhibition of macrophage-mediated cytokine synthesis, suppression of the delayed-type hyper-sensitivity response, and stimulation of the Th2 cell response which results in elevated antibody production. IL-10 functions by inhibiting pro-inflammatory cytokines made by macrophages and regulatory T cells including IFN-gamma, TNF-alpha, IL-2, and IL-3, IL-4, and GM-CSF. IL-10 is also known to suppress antigen presentation on antigen presenting cells, enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. While human IL-10 can act on murine cells, murine IL-10 cannot act on human cells. Binds to a retinoid X receptor (RXR) responsive element
Category | Antibody |
Supplier | ThermoFisher |
Application | N, WB |
Regulatory Status | RUO |
Immunogen | E. coli-derived recombinant human IL-10 Ser19-Asn178 |
Host | Ms |
Clone Number | [25209] |
Genebank | IL10 |
Isotype | IgG2b |
Crossreactivity | Hu |
Clonality | Mab |
Format | Lyophilized; PBS; , with 5% trehalose and No Preservative |
Concentration | 0.5 mg/mL |
Working Dilution | Neutralization (0.005-0.03 µg/mL), Western Blot (5 µg/mL) |
Purity | Protein A/G |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Disclaimer | Alternative CatNo: MA5-23716 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |