IFN gamma Monoclonal Antibody (25718)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA523718 | 500 µg | 682,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method. IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor, and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists, functionally, as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20 and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines. Activation of IFN gamma takes place through binding of IFN gamma receptor I and II, and activating the JAK-STAT pathway. IFN gamma does not show any homo
Category | Antibody |
Supplier | ThermoFisher |
Application | FC, ICC, N |
Regulatory Status | RUO |
Immunogen | E. coli-derived recombinant human IFN- gamma Gln24-Gln166 |
Host | Ms |
Clone Number | [25718] |
Genebank | IFNG |
Isotype | IgG2a |
Crossreactivity | Hu |
Clonality | Mab |
Format | Lyophilized; PBS; , with 5% trehalose and No Preservative |
Concentration | 0.5 mg/mL |
Working Dilution | Immunocytochemistry (8-25 µg/mL), Neutralization (0.02-0.06 µg/mL), Flow Cytometry (0.25 µg/10^6 ... |
Purity | Protein A/G |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Disclaimer | Alternative CatNo: MA5-23718 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |