VEGF Monoclonal Antibody (26503)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA523719 | 500 µg | 648,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
In ELISAs, this antibody shows approximately 10% cross-reactivity with recombinant mouse (rm) VEGF and rrVEGF and no cross-reactivity with rhVEGF-D. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method. VEGF (vascular endothelial growth factor) which is a 45 kDa homodimeric, disulfide-linked glycoprotein involved in angiogenesis which promotes tumor progression and metastasis. VEGF has a variety of effects on vascular endothelium, including the ability to promote endothelial cell viability, mitogenesis, chemotaxis, and vascular permeability. The VEGF family currently includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and PIGF. VEGF and its receptor system have been shown to be the fundamental regulators in the cell signaling of angiogenesis. Most tumors have the absolute requirement of angiogenesis, and VEGF has been described as the most potent angiogenic cytokine linked to this process. To date 5 different isoforms of VEGF have been described. These isoforms are generated as the result of alternative splicing from a single VEGF gene. These various isoforms have been shown to bind to two tyrosine-kinase receptors flt-1 (VEGFR-1) and flk-1/KDR (VEGFR-2), which have been found to be expressed almost exclusive
Category | Antibody |
Supplier | ThermoFisher |
Application | EL, N, WB |
Regulatory Status | RUO |
Immunogen | Sf 21-derived recombinant human VEGF165 Ala27-Arg191 |
Host | Ms |
Clone Number | [26503] |
Genebank | VEGFA |
Isotype | IgG2b |
Crossreactivity | Hu, Primate |
Clonality | Mab |
Format | Lyophilized; PBS; , with 5% trehalose and No Preservative |
Concentration | 0.5 mg/mL |
Working Dilution | ELISA (0.1-0.4 µg/mL (Detection), 2-8 µg/mL (Capture)), Neutralization (10-60 ng/mL), Western Blo... |
Purity | Protein A/G |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Disclaimer | Alternative CatNo: MA5-23719 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |