Thrombopoietin Monoclonal Antibody (34817)
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| MA523731 | 500 µg | 658,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
In sandwich ELISAs, no cross-reactivity or interference with recombinant human (rh) G-CSF, rhG-CSF R, rhGM-CSF, recombinant mouse GM-CSF, or rhM-CSF is observed. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method. Thrombopoietin (TPO, THPO, MPL ligand, megakaryocyte colony-stimulating factor) is responsible for the generation of platelets through its action on hematopoietic cells committed to the megakaryocyte lineage. Binding of thrombopoietin to its receptor, MPL (CD110), initiates a signaling cascade via JAK/STAT, MAPK, and PI3K/AKT signaling pathways that leads to the proliferation and differentiation of megakaryocytes and, ultimately, to the production of platelets (thrombopoiesis). Thrombopoietin is constitutively produced by the liver and has a predicted molecular weight of 38 kDa.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | EL, N |
| Regulatory Status | RUO |
| Immunogen | Sf 21-derived recombinant human Thrombopoietin/Tpo Ser22-Gly353 |
| Host | Ms |
| Clone Number | [34817] |
| Genebank | THPO |
| Isotype | IgG2b |
| Crossreactivity | Hu |
| Clonality | Mab |
| Format | Lyophilized; PBS; , with 5% trehalose and No Preservative |
| Concentration | 0.5 mg/mL |
| Working Dilution | ELISA (0.1-2 µg/mL (Detection), 2-8 µg/mL (Capture)), Neutralization (5-10 µg/mL) |
| Purity | Protein A/G |
| Conjugation | Unconjugated |
| Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
| Disclaimer | Alternative CatNo: MA5-23731 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
