IL-17A Monoclonal Antibody (41809)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA523738 | 500 µg | 682,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
In direct ELISAs, approximately 12% cross-reactivity with recombinant canine IL-17 is observed and 25%-50% reactivity with recombinant human (rh) IL-17A/IL-17F heterodimer is observed. No cross-reactivity with recombinant mouse IL-17, rhIL-17B, rhIL-17C, rhIL-17D, rhIL-17E, or rhIL-17F is observed. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method. Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and i
Category | Antibody |
Supplier | ThermoFisher |
Application | EL, IHC, IP, N |
Regulatory Status | RUO |
Immunogen | E. coli-derived recombinant human IL-17 Ile20-Ala155 |
Host | Ms |
Clone Number | [41809] |
Genebank | IL17A |
Isotype | IgG2b |
Crossreactivity | Hu, Primate |
Clonality | Mab |
Format | Lyophilized; PBS; , with 5% trehalose and No Preservative |
Concentration | 0.5 mg/mL |
Working Dilution | Immunohistochemistry (5-25 µg/mL), ELISA (0.1-0.4 µg/mL (Detection), 2-8 µg/mL (Capture)), Immuno... |
Purity | Protein A/G |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Disclaimer | Alternative CatNo: MA5-23738 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |