IL-17 A/F Monoclonal Antibody (50104)
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| MA523748 | 500 µg | 682,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
In direct ELISAs, approximately 40% reactivity with recombinant mouse (rm) IL-17A/IL-17F heterodimer is observed. No cross-reactivity with recombinant human IL-17, recombinant canine IL-17, rmIL-17B, rmIL-17C, rmIL-17D, rmIL-17E, or rmIL-17F is observed. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method. IL-17A and IL-17F are well-characterized homodimeric cytokines secreted by T helper 17 (Th17) cells, gamma-delta T cells and several subsets of innate lymphoid cells. Somewhat less appreciated, IL-17A and IL-17F subunits can also form the heterodimer, IL-17AF. Together, these three dimers signal through the IL-17RA/IL-17RC receptor complex to mediate immune responses at mucosal interfaces and are found at lesion sites in inflammatory bowel disease, asthma, atopic dermatitis and rheumatoid arthritis.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | N, WB |
| Regulatory Status | RUO |
| Immunogen | E. coli-derived recombinant mouse IL-17 Thr22-Ala158 |
| Host | Rt |
| Clone Number | [50104] |
| Genebank | IL17A |
| Isotype | IgG2a |
| Crossreactivity | Ms |
| Clonality | Mab |
| Format | Lyophilized; PBS; , with 5% trehalose and No Preservative |
| Concentration | 0.5 mg/mL |
| Working Dilution | Neutralization (0.05-0.15 µg/mL), Western Blot (1 µg/mL) |
| Purity | Protein A/G |
| Conjugation | Unconjugated |
| Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
| Disclaimer | Alternative CatNo: MA5-23748 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
