CD178 Monoclonal Antibody (100419)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA523765 | 500 µg | 602,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method. CD178 (Fas ligand, FasL) is a type-II-membrane protein, whose N-terminus is in the cytoplasm and its C-terminal region extends into the extracellular space. Its receptor, FasR, is a cell-surface-type-I-membrane protein and a member of the tumor necrosis factor (TNF) and nerve growth factor (NGF) receptor family. As a member of the TNF-cytokine family CD178 induces apoptosis when interacting with FasR. CD178 may exist as either membrane bound (45 kD) or soluble forms (26 kD). The soluble protein can be released from cells upon cleavage by metalloproteinases. Binding of CD178 to Fas leads to oligomerization of the receptor and triggers apoptotic cell death through the interaction of other proteins. CD178 is predominantly expressed in activated T-lymphocytes and natural killer (NK) cells also it is expressed in the tissues of immune-privilege sites such as testis and eye. CD178 expression is also reported in various tissues as thymus, liver, ovary, lung, heart and kidney. It is assumed that induction of apoptosis through CD178 is predominantly involved in anti-viral immune responses. CD178 is a cell surface molecule belonging to the tumor necrosis factor f
Category | Antibody |
Supplier | ThermoFisher |
Application | EL, FC, N |
Regulatory Status | RUO |
Immunogen | CHO-derived recombinant human Fas Ligand/TNFSF6 Pro134-Leu281 |
Host | Ms |
Clone Number | [100419] |
Genebank | FASLG |
Isotype | IgG2b |
Crossreactivity | Hu |
Clonality | Mab |
Format | Lyophilized; PBS; , with 5% trehalose and No Preservative |
Concentration | 0.5 mg/mL |
Working Dilution | ELISA (0.1-0.4 µg/mL (Detection), 2-8 µg/mL (Capture)), Neutralization (1-5 ng/mL), Flow Cytometr... |
Purity | Protein A/G |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Disclaimer | Alternative CatNo: MA5-23765 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |