IL-29 Monoclonal Antibody (247801)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA523791 | 500 µg | 786,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
In sandwich ELISAs, 100% cross-reactivity with recombinant human (rh) IL-28B/IFN-lambda 3 and 20% with rhIL-28A is observed. No cross-reactivity or interference was observed with rhIFN-alpha A, rhIFN-alpha B2, rhIFN-alpha G, rhIFN-alpha I, or rhIFN- beta 1A. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method. IFN-lambdas constitute a novel family of interferons that mediate the induction of anti-viral protection in a wide variety of cells. There are three members in this family, namely lambda1, lambda2, and lambda3, which are also known as IL-29, IL-28A, and IL-28B, respectively. Similar to type I IFNs, IFN-lambdas activate an intracellular signaling to promote gene expression. IFN-lambdas mediate their anti-viral protection through a class II cytokine receptor complex composed of two essential receptor proteins, CRF2-12/IFN-lambdaR1, which is unique to IFN-lambdas, and CFR2-4/IL-10R2, which is shared with IL-10, IL-22, and IL-26 receptors. The IFN-lambdas, IL-28 and IL-29, have recently been reported to prime dendritic cells to induce proliferation of Foxp3-bearing regulatory T cells. DCs that differentiate in response to IFN-lambdas express high levels of class I and II MHC gene products, but low level
Category | Antibody |
Supplier | ThermoFisher |
Application | EL, N |
Regulatory Status | RUO |
Immunogen | Mouse myeloma cell line NS0-derived recombinant human IL-29/IFN-lambda 1 Gly20-Thr200 |
Host | Ms |
Clone Number | [247801] |
Genebank | IFNL1 |
Isotype | IgG2a |
Crossreactivity | Hu |
Clonality | Mab |
Format | Lyophilized; PBS; , with 5% trehalose and No Preservative |
Concentration | 0.5 mg/mL |
Working Dilution | Neutralization (1-4 µg/mL), ELISA (0.1-0.4 µg/mL (Detection), 2-8 µg/mL (Capture)) |
Purity | Protein A/G |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Disclaimer | Alternative CatNo: MA5-23791 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |