TGF beta-1,2,3 Monoclonal Antibody (1D11)

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Product Description

This antibody recognizes human TGF-beta 1, TGF-beta 2, and TGF-beta 3. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method. Neutralization: measured by its ability to neutralize TGF beta-1 inhibition of IL-4-dependent proliferation in the HT-2 mouse T cell line. The Neutralization Dose (ND50) is typically 0.25-1.25 µg/mL in the presence of 1 ng/mL Recombinant Human TGF beta-1 and 7.5 ng/mL Recombinant Mouse IL-4. TGF-beta1, -2, and -3 are a closely related group of proteins (70-80% sequence homology) that are produced by many cell types and function as growth and differentiation factors. The active forms of TGF-beta1, -2, and -3 are disulfide-linked homodimers.