ORC1 Monoclonal Antibody (ORC1 7F6/1)
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| MA524770 | 100 µg | 684,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | ChIP, EL, IHC, IP, WB |
| Regulatory Status | RUO |
| Research Field | PROTEIN & CELL ANALYSIS |
| Immunogen | Bacterially expressed Human ORC1. |
| Host | Ms |
| Clone Number | [ORC1 7F6/1] |
| Genebank | ORC1 |
| Isotype | IgG1 |
| Crossreactivity | Hu |
| Clonality | Mab |
| Format | Liquid; PBS; , with 0.02% sodium azide |
| Concentration | 1 mg/mL |
| Working Dilution | Western Blot (1:100-1:2,000), ELISA (1:100-1:2,000), Immunoprecipitation (1:10-1:500), Immunohist... |
| Purity | Protein A/G |
| Conjugation | Unconjugated |
| Storage Conditions | Freezer (-5 to -30 C) |
| Disclaimer | Alternative CatNo: MA5-24770 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Shipping Details | Ambient |
| Material Safety Data Sheet | Download PDF |
