Torc1 Monoclonal Antibody (2D4)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA524872 | 100 µL | 662,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons. In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. [UniProt]
Category | Antibody |
Supplier | ThermoFisher |
Application | WB |
Regulatory Status | RUO |
Immunogen | Recombinant full length Human TORC1. |
Host | Ms |
Clone Number | [2D4] |
Genebank | CRTC1 |
Isotype | IgM |
Crossreactivity | Hu, Ms, Primate, Rt |
Clonality | Mab |
Format | Liquid; PBS; pH 7.4, with 50% glycerol and 0.02% sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Western Blot (1:1,000-1:2,000) |
Purity | Antigen affinity chromatography |
Conjugation | Unconjugated |
Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Disclaimer | Alternative CatNo: MA5-24872 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |