Phospho-EGFR (Tyr1068) Recombinant Rabbit Monoclonal Antibody (EGFRY1068-E5), FITC
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA527995 | 100 Tests | 429,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire. EGFR (Epidermal growth factor receptor, HER1, ErbB1) is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. Phosphorylation of EGFR at certain residues is also mediated by Src-non-receptor kinase. EGFR activation signals multiple downstream signaling cascades such as the Ras - ERK, PI3-K - Akt, Jak - STAT and PKC p
Category | Antibody |
Supplier | ThermoFisher |
Application | FC |
Regulatory Status | RUO |
Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr1068 of human phospho EGFR. |
Host | Rb |
Clone Number | [EGFRY1068-E5] |
Genebank | EGFR |
Isotype | IgG,k |
Crossreactivity | Hu, Ms, Rt |
Clonality | Recombi |
Format | Liquid; PBS; pH 7.4, with 0.2% BSA and 0.09% sodium azide |
Working Dilution | Flow Cytometry (5 µL/1x10^6 cells) |
Purity | Protein A/G |
Conjugation | FITC |
Storage Conditions | 4° C, store in dark |
Disclaimer | Alternative CatNo: MA5-27995 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |