CD45RO Monoclonal Antibody (IL-A116), PE
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA528402 | 100 Tests | 642,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Mouse anti Bovine CD45RO, clone IL-A116 recognizes the bovine homologue of the human CD45RO cell surface antigen. CD45RO (UCHL1, ubiquitin carboxyl terminal esterase L1) is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RO is expressed on macrophages, CD8+ T cells, activated T cells and myeloma cells. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
Category | Antibody |
Supplier | ThermoFisher |
Application | FC |
Regulatory Status | RUO |
Immunogen | Bovine peripheral blood mononuclear cells |
Host | Ms |
Clone Number | [IL-A116] |
Genebank | PTPRC |
Isotype | IgG3 |
Crossreactivity | Bo |
Clonality | Mab |
Format | Lyophilized; PBS; , with 1% BSA, 5% sucrose and 0.09% sodium azide |
Working Dilution | Flow Cytometry (Assay-dependent) |
Purity | Protein A |
Conjugation | PE |
Storage Conditions | 4° C, store in dark, DO NOT FREEZE! |
Disclaimer | Alternative CatNo: MA5-28402 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |