DUSP2 Monoclonal Antibody (PAC-1)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA528523 | 100 µg | 199,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
The mouse monoclonal antibody PAC-1 recognizes an activation-induced conformational epitope PAC-1 on CD41/CD61 complex (gpIIb/IIIa), also known as integrin alpha IIb beta 3, a receptor which mediates platelet aggregation. The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus.
Category | Antibody |
Supplier | ThermoFisher |
Application | FC, ICC, IP |
Regulatory Status | RUO |
Immunogen | Human platelets |
Host | Ms |
Clone Number | [PAC-1] |
Genebank | DUSP2 |
Isotype | IgM,k |
Crossreactivity | Hu |
Clonality | Mab |
Format | liquid; TBS; pH 8, with 15mM sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Immunocytochemistry (Assay-Dependent), Immunoprecipitation (Assay-Dependent), Flow Cytometry (2-4... |
Purity | Ion-exchange chromatography/PEG precipitation |
Conjugation | Unconjugated |
Storage Conditions | 4° C, do not freeze |
Disclaimer | Alternative CatNo: MA5-28523 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |