CD54 (ICAM-1) Monoclonal Antibody (1H4), Alexa Fluor™ 700
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA528553 | 100 Tests | 346,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
The antibody 1H4 reacts with CD54 (ICAM-1), a 85-110 kDa type I transmembrane glycoprotein (receptor for rhinovirus) expressed on activated endothelial cells, T lymphocytes, B lymphocytes, monocytes, macrophages, granulocytes and dendritic cells; the expression of CD54 is upregulated by activation. Recommended dilution is for 100 µL of whole blood or 1x10^6 cells in suspension. ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various i
Category | Antibody |
Supplier | ThermoFisher |
Application | FC |
Regulatory Status | RUO |
Immunogen | Raji cells and spleen cells fused with NS1 cells |
Host | Ms |
Clone Number | [1H4] |
Genebank | ICAM1 |
Isotype | IgG2b |
Crossreactivity | Hu |
Clonality | Mab |
Format | liquid; PBS; pH 7.4, with 0.2% BSA and 15mM sodium azide |
Working Dilution | Flow Cytometry (4 µL/1x10^6 cells) |
Purity | Size-exclusion chromatography |
Conjugation | Alexa Fluor 700 |
Storage Conditions | 4° C, store in dark, DO NOT FREEZE! |
Disclaimer | Alternative CatNo: MA5-28553 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |