CD137 (4-1BB) Monoclonal Antibody (4B4-1)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA528559 | 100 µg | 171,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
The mouse monoclonal antibody 4B4-1 recognizes CD137, an approximately 40 kDa type I transmembrane protein of the TNFR family expressed mainly on activated T cells. Low endotoxin azide free phosphate buffered saline (PBS) solution, 0.2 µm filter sterilized. Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test. Functional Application: Inhibition. CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.
Category | Antibody |
Supplier | ThermoFisher |
Application | EL, FC, IP |
Regulatory Status | RUO |
Immunogen | Recombinant human CD137 ectodomain |
Host | Ms |
Clone Number | [4B4-1] |
Genebank | TNFRSF9 |
Isotype | IgG1,k |
Crossreactivity | Baboon, Chimpanzee, Cynomolgus Monkey, Hu, Primate, Rhesus Monkey |
Clonality | Mab |
Format | liquid; PBS; pH 7.4, with no preservative |
Concentration | 1 mg/mL |
Working Dilution | Immunoprecipitation (Assay-Dependent), Functional Assay (Assay-Dependent), ELISA (Assay-Dependent... |
Purity | Protein A |
Conjugation | Unconjugated |
Storage Conditions | 4° C, do not freeze |
Disclaimer | Alternative CatNo: MA5-28559 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |