CD137 (4-1BB) Monoclonal Antibody (4B4-1)
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| MA528560 | 100 µg | 172,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
The mouse monoclonal antibody 4B4-1 recognizes CD137, an approximately 40 kDa type I transmembrane protein of the TNFR family expressed mainly on activated T cells. CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | EL, FC, IP |
| Regulatory Status | RUO |
| Immunogen | Recombinant human CD137 ectodomain |
| Host | Ms |
| Clone Number | [4B4-1] |
| Genebank | TNFRSF9 |
| Isotype | IgG1,k |
| Crossreactivity | Baboon, Chimpanzee, Cynomolgus Monkey, Hu, Primate, Rhesus Monkey |
| Clonality | Mab |
| Format | liquid; PBS; pH 7.4, with 15mM sodium azide |
| Concentration | 1 mg/mL |
| Working Dilution | ELISA (Assay-Dependent), Flow Cytometry (1-4 µg/mL), Immunoprecipitation (Assay-Dependent) |
| Purity | Protein A |
| Conjugation | Unconjugated |
| Storage Conditions | 4° C, do not freeze |
| Disclaimer | Alternative CatNo: MA5-28560 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
